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RESEARCH PLATFORM 1

R.P 1.1 Development and Clinical Validation of AI-Based Software as a Medical Device for Non-Invasive Ophthalmic Imaging and Automated Reporting

Development and Clinical Validation of AI-Based Software as a Medical Device for Non-Invasive Ophthalmic Imaging and Automated Reporting

Principle Investigators

PolyU

Prof. Mingguang HE

UWaterloo

Prof. Stanley WOO

Co-I

Dr. Yanxian CHEN

Prof. Chea-su KEE

Dr. Danli SHI

Dr. Xianwen SHANG

Overview

Traditional ophthalmic imaging techniques, such as fundus fluorescein angiograms and indocyanine green angiography, are crucial for diagnosing retinal conditions but are invasive and uncomfortable for patients. This project aims to develop and clinically validate advanced AI-based software as a medical device for non-invasive ophthalmic imaging and automated diagnostic reporting. The study applies generative adversarial networks (GANs) to transform standard fundus photographs into angiography-like images, eliminating the need for invasive procedures. The work focuses on refining these AI models, integrating them into a user-friendly and regulatory-compliant platform, and conducting rigorous clinical validation for retinal conditions such as diabetic retinopathy and age-related macular degeneration.

Learn more about R.P 1.2

R.P 1.2 Anti-Myopia Electronic Displays: Making Screens Eye-Safe for Children

R.P 1.3 Advanced Technologies for Prediction of Myopia Progression

R.P 1.4 Targeting Higher-Level Brain Functions for Amblyopia Rehabilitation

R.P 1.5 Novel Neuromodulation Approaches for Vision Enhancement in Adults

R.P 2.1 Clinical Translation of a Novel Anti-Microbial Therapy for Eye Infections

R.P 2.2 An Organoid Platform and Cell-Based Platform for Ocular Therapeutic Development

R.P 2.3 Developing Next-Generation Therapeutic Agents for Glaucoma

R.P 2.4 Novel Gene Delivery Platforms for the Treatment of Ocular Disease

R.P 2.5 Integrated Dry Eye Diagnosis and Precision Therapies

R.P 2.6 Development of Ocular Inserts and Aptamer-Based Delivery Vehicles for Sustained Release of Ocular Therapeutics and TCM Products

R.P 3.1 Eye Disease Diagnosis and Treatment Enabled by Novel Retinal Instrumentation

R.P 3.2 Non-Invasive Tear-Based Diagnostic System

R.P 3.3 Development of New-Generation Contact Lenses Using Novel Materials and Additive Manufacturing

R.P 3.4 Detection of Macular Degeneration and Myopia-Induced Retinal Damage Using Structured Light Technology

R.P 3.5 Extended Reality Visual Intelligence System (XRVIS) for Tele-Visual Assessment and Safety Enhancement for People with Visual Impairment

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