R.P 2.1 Clinical Translation of a Novel Anti-Microbial Therapy for Eye Infections

Work to be Done

Comprehensive preclinical testing is essential to define the therapeutic index and guide future clinical trials, advancing this antimicrobial combination therapy toward regulatory approval and clinical use. Key tasks include:

• Efficacy & Safety Testing: Assessing treatment effects through bacterial load, ocular injury scores, immune response markers, and toxicity studies.
• ADME Testing: Evaluating drug absorption, distribution, metabolism, and excretion by analysing plasma and tissue concentrations.
• Pharmacokinetics (PK) Studies: Determining PK parameters after topical administration in mice.

Next-Generation Drug Development: Building on prior CEVR research, the team aims to optimize the therapy through rational drug design, and drug repurposing, by leveraging the unique molecular mechanisms we discovered.