Back

RESEARCH PLATFORM 3

R.P 3.2 Non-Invasive Tear-Based Diagnostic System

Principle Investigators

PolyU

Prof. Chuen Thomas LAM

Prof. Lei Henry ZHOU

UWaterloo

Prof. Scott HOPKINS

Co-I

Prof. Ming-yan Allen CHEONG

Prof. Lyndon JONES

Prof. Juewen LIU

Dr. Chau-minh PHAN

Overview

Tear fluid is rich in molecules such as proteins, lipids, electrolytes, and metabolites, making its metabolomic profile a valuable indicator of overall health. This project aims to develop technologies to detect various biomarkers in tear fluid. The first objective focuses on a multi-omics tear biomarker discovery and validation platform, using high-resolution mass spectrometry combined with bioinformatics and machine learning to identify and quantify clinically relevant proteomic and metabolomic markers. The second objective targets the development of tear based point of care tests, translating validated biomarkers into practical diagnostic kits for conditions such as dry eye disease, glaucoma, retinopathy of prematurity, and contact lens discomfort.

Learn more about R.P 3.1 Learn more about R.P 3.3

R.P 1.1 Development and Clinical Validation of AI-Based Software as a Medical Device for Non-Invasive Ophthalmic Imaging and Automated Reporting

Development and Clinical Validation of AI-Based Software as a Medical Device for Non-Invasive Ophthalmic Imaging and Automated Reporting

R.P 1.2 Anti-Myopia Electronic Displays: Making Screens Eye-Safe for Children

R.P 1.3 Advanced Technologies for Prediction of Myopia Progression

R.P 1.4 Targeting Higher-Level Brain Functions for Amblyopia Rehabilitation

R.P 1.5 Novel Neuromodulation Approaches for Vision Enhancement in Adults

R.P 2.1 Clinical Translation of a Novel Anti-Microbial Therapy for Eye Infections

R.P 2.2 An Organoid Platform and Cell-Based Platform for Ocular Therapeutic Development

R.P 2.3 Developing Next-Generation Therapeutic Agents for Glaucoma

R.P 2.4 Novel Gene Delivery Platforms for the Treatment of Ocular Disease

R.P 2.5 Integrated Dry Eye Diagnosis and Precision Therapies

R.P 2.6 Development of Ocular Inserts and Aptamer-Based Delivery Vehicles for Sustained Release of Ocular Therapeutics and TCM Products

R.P 3.1 Eye Disease Diagnosis and Treatment Enabled by Novel Retinal Instrumentation

R.P 3.3 Development of New-Generation Contact Lenses Using Novel Materials and Additive Manufacturing

R.P 3.4 Detection of Macular Degeneration and Myopia-Induced Retinal Damage Using Structured Light Technology

R.P 3.5 Extended Reality Visual Intelligence System (XRVIS) for Tele-Visual Assessment and Safety Enhancement for People with Visual Impairment

ENQUIRY