R.P 2.6 Development of Ocular Inserts and Aptamer-Based Delivery Vehicles for Sustained Release of Ocular Therapeutics and TCM Products

Overview

The eye's complex physiology and anatomy pose challenges for effective drug delivery to both the anterior and posterior segments. This project aims to develop and validate two synergistic ocular drug delivery systems – an aptamer-based delivery vehicle and biodegradable ocular inserts - for sustained and effective treatment of dry eye disease. Addressing challenges in ocular drug bioavailability and patient compliance, the study integrates advanced biomaterials, aptamer technology, and controlled-release inserts to improve delivery to the eye. Research activities include preclinical evaluation of cornea-binding aptamer liposomes, development of responsive ocular inserts, and systematic screening of traditional Chinese medicine–derived compounds using advanced in-vitro models to identify new therapeutic candidates.