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RESEARCH PLATFORM 2

R.P 2.5 Integrated Dry Eye Diagnosis and Precision Therapies

Principle Investigators

PolyU

Dr. Jingfang Jennifer BIAN

Prof. Chuen Thomas LAM

UWaterloo

Dr. William NGO

Co-I

Prof. Ming-yan Allen CHEONG

Prof. Chi-wai DO

Prof. Simon, Ming-yuen LEE

Dr. Samantha SHAN

Dr. Benqin TANG

Prof. Shujun WANG

Prof. Qian ZHAO

Prof. Daisy ZHAO

Prof. Lei Henry ZHOU

Dr. Liping ZHOU

Prof. Maud GORBET

Prof. Lyndon JONES

Prof. Juewen LIU

Overview

Dry eye disease (DED) is a multifactorial ocular condition that impacts up to 50% of the global population, causing chronic pain and discomfort. This project aims to develop integrated, precision-based diagnostic and therapeutic solutions for DED (through a multidisciplinary approach tailored to Chinese populations. Recognizing the complex and multifactorial nature of DED, the study focuses on advancing molecular diagnostics, AI-assisted clinical assessment, and biomarker discovery. Key research activities include developing aptamer-based corneal staining for accurate diagnosis, AI models trained on population-specific imaging data, tear proteomics to identify disease markers, and evaluation of novel treatments, including traditional Chinese medicine, natural supplements, and advanced drug delivery systems targeting underlying inflammatory and oxidative mechanisms.

Learn more about R.P 2.4 Learn more about R.P 2.6

R.P 1.1 Development and Clinical Validation of AI-Based Software as a Medical Device for Non-Invasive Ophthalmic Imaging and Automated Reporting

Development and Clinical Validation of AI-Based Software as a Medical Device for Non-Invasive Ophthalmic Imaging and Automated Reporting

R.P 1.2 Anti-Myopia Electronic Displays: Making Screens Eye-Safe for Children

R.P 1.3 Advanced Technologies for Prediction of Myopia Progression

R.P 1.4 Targeting Higher-Level Brain Functions for Amblyopia Rehabilitation

R.P 1.5 Novel Neuromodulation Approaches for Vision Enhancement in Adults

R.P 2.1 Clinical Translation of a Novel Anti-Microbial Therapy for Eye Infections

R.P 2.2 An Organoid Platform and Cell-Based Platform for Ocular Therapeutic Development

R.P 2.3 Developing Next-Generation Therapeutic Agents for Glaucoma

R.P 2.4 Novel Gene Delivery Platforms for the Treatment of Ocular Disease

R.P 2.6 Development of Ocular Inserts and Aptamer-Based Delivery Vehicles for Sustained Release of Ocular Therapeutics and TCM Products

R.P 3.1 Eye Disease Diagnosis and Treatment Enabled by Novel Retinal Instrumentation

R.P 3.2 Non-Invasive Tear-Based Diagnostic System

R.P 3.3 Development of New-Generation Contact Lenses Using Novel Materials and Additive Manufacturing

R.P 3.4 Detection of Macular Degeneration and Myopia-Induced Retinal Damage Using Structured Light Technology

R.P 3.5 Extended Reality Visual Intelligence System (XRVIS) for Tele-Visual Assessment and Safety Enhancement for People with Visual Impairment

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